Understanding MTHFR, Dirty Genes & Nutrition

Imagine two people following the exact same "healthy" diet—one thrives with abundant energy and stable moods, while the other still struggles with fatigue, anxiety, and brain fog. This common scenario highlights a crucial truth: when it comes to nutrition and wellness, one size does not fit all. The emerging field of nutrigenomics helps explain why, revealing how genetic variations like MTHFR mutations can dramatically affect our ability to benefit from even the most nutritious foods.
The MTHFR gene plays a starring role in methylation—a fundamental biochemical process that affects everything from neurotransmitter production to detoxification to DNA repair. When this gene has variations (which nearly half of people do to some degree), it can impair the body's ability to activate folate and other B vitamins, leading to a cascade of potential issues including mood disorders, chronic inflammation, and difficulty clearing toxins. Other "dirty genes" like COMT or GST further complicate the picture, influencing how we handle stress, process hormones, and eliminate environmental toxins.
What makes this particularly relevant for trauma survivors is the bidirectional relationship between genes and experience. Chronic stress and trauma deplete the very nutrients (like B vitamins, magnesium, and zinc) needed for optimal gene expression, while genetic variations can make individuals more susceptible to stress's damaging effects. It's a vicious cycle that explains why some people seem to struggle more with recovery than others.
At TLOEP, we approach this complexity with personalized strategies. Through programs like Learn Your Value™, we help clients understand their unique genetic terrain through testing and interpretation. More importantly, we translate this knowledge into actionable steps—whether it's emphasizing methylated forms of B vitamins for those with MTHFR variants, supporting detox pathways for those with GST mutations, or tailoring macronutrient ratios based on COMT status. We combine this with trauma-informed nervous system support, recognizing that no supplement can compensate for an overwhelmed autonomic nervous system.
The empowering truth is that while we can't change our genes, we can profoundly influence how they express themselves. By combining genetic insight with trauma-informed care, we help clients create truly personalized roadmaps to resilience.

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